Description

Pyrrolo[1,2-A]Pyrazin-1(2H)-One, Hexahydro-3-(Hydroxymethyl)-, (3S,8As)- (9Ci) is a high-purity, stereochemically defined heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a fused pyrrolo-pyrazinone scaffold with a hydroxymethyl substituent, makes it a valuable intermediate for constructing complex pharmacologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals. Its defined stereochemistry at the 3S and 8aS positions is critical for applications requiring specific chiral interactions.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry Research: Used as a constrained scaffold for structure-activity relationship (SAR) studies and library synthesis to explore new bioactive chemical space.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric transformations due to its inherent chiral centers, facilitating the construction of enantiomerically pure compounds.
• Fine Chemical Production: Acts as a precursor in the multi-step synthesis of complex, high-value specialty chemicals for agrochemical and material science applications.
• Academic Research: Utilized in universities and research institutes for methodological development in heterocyclic and synthetic organic chemistry.

Basic Information

Item	Details
Product Name	Pyrrolo[1,2-A]Pyrazin-1(2H)-One, Hexahydro-3-(Hydroxymethyl)-, (3S,8As)- (9Ci)
CAS No.	650577-97-2
Molecular Formula	C8H14N2O2
Molecular Weight	170.21 g/mol
Synonyms	(3S,8aS)-Hexahydro-3-(hydroxymethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one; (3S,8aS)-3-(Hydroxymethyl)octahydropyrrolo[1,2-a]pyrazin-1-one; Hexahydro-3-(hydroxymethyl)-, (3S,8aS)-Pyrrolo[1,2-a]pyrazin-1(2H)-one; (3S,8aS)-3-Hydroxymethyl-octahydro-pyrrolo[1,2-a]pyrazin-1-one; Chiral Pyrrolopyrazinone Building Block
EINECS	Contact for details

Quality Control

Every batch of our Pyrrolo[1,2-A]Pyrazin-1(2H)-One, Hexahydro-3-(Hydroxymethyl)-, (3S,8As)- (9Ci) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, critical for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (HPLC), and residual solvents are available upon request. Our quality commitment aligns with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.