Description

Methyl 4-Fmoc-Piperazine-2-Carboxylate CAS NO 647004-81-7 is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical Fmoc-protected building block, enabling the controlled introduction of a piperazine moiety into complex molecular architectures. It is an essential reagent for medicinal chemists and process development scientists working on new drug candidates, particularly in the fields of oncology, neurology, and infectious diseases.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the automated synthesis of therapeutic peptides and peptidomimetics.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of novel active pharmaceutical ingredients (APIs) containing modified piperazine scaffolds.
• Combinatorial Chemistry Libraries: Serves as a versatile building block for creating diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Employed in the optimization and kilogram-scale production of peptide-based drugs and diagnostic agents.
• Bioconjugation: Facilitates the site-specific modification of proteins, antibodies, and other biomolecules for targeted drug delivery systems.
• Chemical Biology Probes: Used to synthesize labeled probes for studying enzyme mechanisms and protein-protein interactions.

Basic Information

Product Name	Methyl 4-Fmoc-Piperazine-2-Carboxylate
CAS No.	647004-81-7
Molecular Formula	C22H24N2O5
Molecular Weight	396.44 g/mol
Synonyms	Methyl 4-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-piperazinecarboxylate; 1-Fmoc-4-Carbomethoxy-2-piperazinecarboxylic Acid Methyl Ester; 4-(Fmoc-amino)-2-piperazinecarboxylic Acid Methyl Ester; Fmoc-Pip(4-OMe)-OH; Methyl 1-Fmoc-piperazine-2-carboxylate; Methyl N-Fmoc-piperazine-2-carboxylate; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxycarbonylpiperazine-2-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 4-Fmoc-Piperazine-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support regulatory filings with full traceability and documentation in compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0% (Total impurities ≤3.0%)
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.