Description

4-Carboxymethyl-4-Phenyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for the synthesis of complex active pharmaceutical ingredients (APIs). Its value lies in its role as a versatile building block, enabling the efficient construction of specific piperidine-based pharmacophores found in modern therapeutics. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and fine chemical industries, particularly those focused on central nervous system (CNS) and analgesic drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development and commercial production of novel piperidine-based pharmaceuticals.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), especially those targeting neurological pathways.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing for high-value, low-volume specialty chemicals.
• Process Chemistry Development: Utilized in route scouting and optimization for scalable and cost-effective manufacturing processes.

Basic Information

Product Name	4-Carboxymethyl-4-Phenyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	644982-20-7
Molecular Formula	C18H25NO4
Molecular Weight	319.40 g/mol
Synonyms	1-Boc-4-(carboxymethyl)-4-phenylpiperidine; 4-Phenyl-4-(carboxymethyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(carboxymethyl)-4-phenylpiperidine-1-carboxylate; 4-(Carboxymethyl)-4-phenyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(carboxymethyl)-4-phenylpiperidine; 4-Phenyl-1-Boc-piperidine-4-acetic acid; BOC-4-Phenyl-4-piperidineacetic acid
EINECS	Contact for details

Quality Control

Our 4-Carboxymethyl-4-Phenyl-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.