Description

tert-Butyl 4-(5-Fluoro-2-Methoxybenzyl)-4-Hydroxypiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and protected amine functionality. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly within central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Synthesis: Used in the construction of complex molecules designed to inhibit specific enzymatic targets.
• Chemical Biology Probes: Employed in the development of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development and exploratory synthetic chemistry.

Basic Information

Product Name	tert-Butyl 4-(5-Fluoro-2-Methoxybenzyl)-4-Hydroxypiperidine-1-Carboxylate
CAS No.	644968-01-4
Molecular Formula	C18H26FNO4
Molecular Weight	339.41 g/mol
Synonyms	1-Boc-4-(5-Fluoro-2-methoxybenzyl)-4-hydroxypiperidine; 4-(5-Fluoro-2-Methoxybenzyl)-4-Hydroxy-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; tert-Butyl 4-hydroxy-4-[(5-fluoro-2-methoxyphenyl)methyl]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(5-fluoro-2-methoxybenzyl)-4-hydroxypiperidine; 4-Hydroxy-4-(5-fluoro-2-methoxybenzyl)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(5-Fluoro-2-methoxybenzyl)-4-hydroxypiperidine; 644968-01-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Fluoro-2-Methoxybenzyl)-4-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.