Description

2,5-Piperazinedione,3-(3-Aminopropyl)-6-Methyl-,(3S,6S)-(9Ci) is a chiral, non-proteinogenic amino acid derivative belonging to the piperazinedione (diketopiperazine) class of compounds. This high-purity intermediate is of significant value for its role in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily sought after by research institutions and manufacturers in the life sciences sector for applications in medicinal chemistry, peptide mimetics, and as a building block for novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in oncology and neurology.
• Peptidomimetic Scaffold: Used in the design and synthesis of peptide mimetics to improve metabolic stability and bioavailability of drug candidates.
• Medicinal Chemistry Research: Serves as a constrained building block in combinatorial chemistry and library synthesis for drug discovery programs.
• Bioconjugation: The functional groups allow for use in linker chemistry for antibody-drug conjugates (ADCs) or other targeted therapies.
• Chemical Biology Probes: Utilized in the development of chemical probes to study enzyme function and biological pathways.
• Asymmetric Synthesis: Employed as a chiral auxiliary or template in stereoselective synthetic routes.

Basic Information

Product Name	2,5-Piperazinedione,3-(3-Aminopropyl)-6-Methyl-,(3S,6S)-(9Ci)
CAS No.	643755-43-5
Molecular Formula	C8H15N3O2
Molecular Weight	185.22 g/mol
Synonyms	(3S,6S)-3-(3-Aminopropyl)-6-methylpiperazine-2,5-dione; (3S,6S)-3-(3-Aminopropyl)-6-methyl-2,5-piperazinedione; (3S,6S)-3-(3-Aminopropyl)-6-methylpiperazine-2,5-dione (9CI); L-3-(3-Aminopropyl)-6-methyl-2,5-diketopiperazine; (S,S)-3-(3-Aminopropyl)-6-methyl-2,5-diketopiperazine; Diketopiperazine derivative CAS 643755-43-5; Chiral piperazinedione building block.
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,3-(3-Aminopropyl)-6-Methyl-,(3S,6S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.