Description

3,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive nitrogen-containing scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for API synthesis and lead optimization.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Peptidomimetic Chemistry: Used to introduce constrained, substituted piperazine motifs into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Synthesis: Intermediate in the production of novel herbicides, fungicides, and insecticides that require specific nitrogen heterocycle architectures.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of novel chemical entities for clients.
• Polymer Modification: Can be used to incorporate functional amine groups into polymer chains for specialty materials.

Basic Information

Product Name	3,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	639068-43-2
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-3,5-dimethylpiperazine; tert-Butyl 3,5-dimethylpiperazine-1-carboxylate; 3,5-Dimethyl-1-N-Boc-piperazine; 1-(tert-Butoxycarbonyl)-3,5-dimethylpiperazine; 3,5-Dimethylpiperazine-1-carboxylic acid tert-butyl ester; N-Boc-3,5-dimethylpiperazine; Boc-3,5-dimethylpiperazine; 1-N-Boc-3,5-dimethylpiperazine
EINECS	Contact for details

Quality Control

Our 3,5-Dimethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.