Description

2-Chloro-6-(4-Methylphenyl)Pyrazine is a high-purity, synthetically valuable pyrazine derivative. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel ligands for catalytic systems and material science applications.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for biochemical probes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Chloro-6-(4-Methylphenyl)Pyrazine
CAS No.	637352-85-3
Molecular Formula	C11H9ClN2
Molecular Weight	204.66 g/mol
Synonyms	2-Chloro-6-p-tolylpyrazine; 6-Chloro-3-(4-methylphenyl)pyrazine; 2-Chloro-6-(4-methylphenyl)pyrazine; 2-Chloro-6-(p-tolyl)pyrazine; 4-(6-Chloropyrazin-2-yl)toluene; p-Tolyl-6-chloropyrazine; (4-Methylphenyl)-6-chloropyrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-(4-Methylphenyl)Pyrazine is manufactured under a strict quality management system. Our products undergo rigorous quality testing including HPLC, GC, NMR, and mass spectrometry to ensure compliance with exacting standards for purity and identity. Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes. We support development from milligram to kilogram scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.