Description

2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine is a high-value, multi-functional heterocyclic building block characterized by its pyrazine core and substituted phenyl ring. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique halogenated and fluorinated structure enables precise molecular modifications. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor research and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the biological activity of the pyrazine moiety.
• Material Science Research: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic semiconductors.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine
CAS No.	637352-84-2
Molecular Formula	C11H6ClF3N2
Molecular Weight	258.63 g/mol
Synonyms	2-Chloro-6-(4-trifluoromethylphenyl)pyrazine; 6-Chloro-3-(4-trifluoromethylphenyl)pyrazine; 2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine; 2-Chloro-6-(alpha,alpha,α-trifluoro-p-tolyl)pyrazine; Pyrazine, 2-chloro-6-[4-(trifluoromethyl)phenyl]-; 637352-84-2
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-[4-(trifluoromethyl)phenyl]pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.