Description

(R)-Piperazine-2-Carboxylic Acid Methyl Ester Dihydrochloride is a high-purity chiral building block and intermediate of significant importance in pharmaceutical research and development. Its defined stereochemistry makes it a critical precursor for synthesizing active pharmaceutical ingredients (APIs) and novel chemical entities, particularly in the areas of central nervous system (CNS) and antiviral therapeutics. This compound is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop enantiomerically pure drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure APIs and drug candidates.
• Medicinal Chemistry Research: Used as a constrained scaffold in structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetics Development: Serves as a building block for creating protease inhibitors and other peptide-like therapeutic molecules.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Chemical Biology Probes: Utilized in the development of tool compounds for target validation and mechanistic studies.
• Process Chemistry: Scalable intermediate for the GMP production of clinical trial materials and commercial drugs.

Basic Information

Product Name	(R)-Piperazine-2-Carboxylic Acid Methyl Ester Dihydrochloride
CAS No.	637027-25-9
Molecular Formula	C7H16Cl2N2O2
Molecular Weight	231.12 g/mol
Synonyms	(R)-Methyl piperazine-2-carboxylate dihydrochloride; (R)-2-Piperazinecarboxylic acid, methyl ester, dihydrochloride; Methyl (R)-piperazine-2-carboxylate dihydrochloride; (R)-Piperazine-2-carboxylic acid methyl ester hydrochloride; (R)-2-Methoxycarbonylpiperazine dihydrochloride; (R)-Methyl 2-piperazinecarboxylate dihydrochloride; (R)-Piperazine-2-methyl carboxylate dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Piperazine-2-Carboxylic Acid Methyl Ester Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.