Description

(R)-1,4-Di-Boc-Piperazine-2-Carboxylic Acid Methyl Ester is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, enantiomerically pure scaffold essential for constructing complex molecules with defined stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), particularly for neurological and oncological targets.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs.
• Peptidomimetic Research: Used to incorporate constrained, stereodefined piperazine units into peptide backbones to enhance stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Chemical Biology Probes: Employed in the creation of tagged molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	(R)-1,4-Di-Boc-Piperazine-2-Carboxylic Acid Methyl Ester
CAS No.	637027-24-8
Molecular Formula	C17H30N2O6
Molecular Weight	358.43 g/mol
Synonyms	(R)-Methyl 1,4-bis(tert-butoxycarbonyl)-2-piperazinecarboxylate; (R)-1,4-Bis-Boc-piperazine-2-carboxylic acid methyl ester; (R)-1,4-Di-tert-butoxycarbonylpiperazine-2-carboxylic acid methyl ester; (R)-1,4-Di-Boc-2-piperazinecarboxylic acid methyl ester; (R)-2-Methoxycarbonyl-1,4-dicarboxylic acid bis-tert-butyl ester piperazine; (R)-1,4-Bis-Boc-piperazine-2-methyl carboxylate; (R)-1,4-Di-Boc-piperazine-2-COOMe
EINECS	Contact for details

Quality Control

Our (R)-1,4-Di-Boc-Piperazine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.