Description

(S)-Octahydro-Pyrido[1,2-A]Pyrazine Hydrochloride CAS NO 635303-45-6 is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. This compound is crucial for the research and development of novel active pharmaceutical ingredients (APIs), particularly in the fields of central nervous system (CNS) and metabolic disorder therapeutics. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in asymmetric synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological receptors.
• Asymmetric Catalysis Research: Used as a precursor or ligand in the development of new catalytic systems for enantioselective transformations.
• Medicinal Chemistry: Serves as a core scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns for drug discovery.
• Process Development & Scale-up: Employed in optimizing synthetic routes from laboratory to pilot and commercial production scales.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API manufacturing.
• Academic Research: Applied in university and institutional research exploring new heterocyclic chemistry and bioactivity.

Basic Information

Product Name	(S)-Octahydro-Pyrido[1,2-A]Pyrazine Hydrochloride
CAS No.	635303-45-6
Molecular Formula	C8H17ClN2
Molecular Weight	176.69 g/mol
Synonyms	(S)-Octahydro-1H-pyrido[1,2-a]pyrazine hydrochloride; (S)-1,2,3,4,6,7,8,8a-Octahydropyrido[1,2-a]pyrazine hydrochloride; (S)-Perhydropyrido[1,2-a]pyrazine hydrochloride; (S)-Hexahydro-1H-pyrido[1,2-a]pyrazine hydrochloride (common misnomer); (S)-2,3,4,6,7,8-Hexahydro-1H-pyrido[1,2-a]pyrazine hydrochloride; (S)-Octahydropyridopyrazine HCl; (S)-OHPP HCl; Chiral bicyclic amine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Octahydro-Pyrido[1,2-A]Pyrazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.