Description

1-n-Boc-4-(2-Chloro-4-Pyridinyl) Piperazine is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile, protected amine functionality.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for target molecules under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents and pesticides.
• Chemical Biology & Proteomics: Utilized as a scaffold or linker in the design of chemical probes and affinity purification reagents.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis organizations (CSOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1-n-Boc-4-(2-Chloro-4-Pyridinyl) Piperazine
CAS No.	633283-63-3
Molecular Formula	C14H20ClN3O2
Molecular Weight	297.78 g/mol
Synonyms	1-Boc-4-(2-chloro-4-pyridinyl)piperazine; tert-Butyl 4-(2-chloro-4-pyridinyl)piperazine-1-carboxylate; 4-(2-Chloro-4-pyridinyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(2-chloro-4-pyridinyl)piperazine; N-Boc-4-(2-chloro-4-pyridinyl)piperazine; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-(2-chloro-4-pyridinyl)-; 2-Chloro-4-(1-Boc-piperazin-4-yl)pyridine
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(2-Chloro-4-Pyridinyl) Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and pharmaceutical development. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with global regulatory frameworks, including REACH and ICH Q7 guidelines for active pharmaceutical ingredient (API) starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.