Description

1-Hexanone,1-(1S,2S,4S)-Bicyclo[2.2.1]Hept-5-En-2-Yl-(9Ci) is a specialized chiral ketone derivative of norbornene, offering a unique bicyclic framework with defined stereochemistry. This compound matters as a high-value chemical intermediate and building block for advanced synthesis, prized for its rigid structure and functional handle. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and advanced materials sectors for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug molecules, particularly those requiring the norbornene scaffold for biological activity or as a synthetic handle.
• Ligand and Catalyst Development: Used in the research and preparation of specialized ligands for asymmetric catalysis, leveraging its defined stereocenters and olefin functionality.
• Advanced Material Monomer: Acts as a functional monomer for the development of specialty polymers with unique thermal or mechanical properties, such as polycyclic olefin copolymers (COC).
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex, polycyclic organic compounds via Diels-Alder and other cycloaddition reactions.
• Fragrance and Flavor Chemistry: Potential use in the synthesis of high-value aroma chemicals where the bicyclic structure contributes to novel olfactory profiles.
• Agrochemical Research: Investigated as an intermediate for novel crop protection agents that benefit from its stereochemically defined, lipophilic framework.

Basic Information

Product Name	1-Hexanone,1-(1S,2S,4S)-Bicyclo[2.2.1]Hept-5-En-2-Yl-(9Ci)
CAS No.	628716-55-2
Molecular Formula	C₁₃H₂₀O
Molecular Weight	192.30 g/mol
Synonyms	1-[(1S,2S,4S)-Bicyclo[2.2.1]hept-5-en-2-yl]hexan-1-one; (1S,2S,4S)-5-Norbornene-2-yl hexyl ketone; (1S,2S,4S)-2-Hexanoylbicyclo[2.2.1]hept-5-ene; endo-5-Norbornen-2-yl hexyl ketone (stereospecific); Norbornenyl hexyl ketone; Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 1-hexyl ester (related); Stereoisomer of norbornene derivative ketone
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral intermediate adheres to strict quality protocols. Every batch is characterized using advanced analytical techniques including Chiral HPLC and NMR to confirm identity, stereochemical purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment, ensuring full traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.