Description

tert-Butyl 4-(2-Formyl-4-(Trifluoromethyl)Phenyl)Piperazine-1-Carboxylate is a high-value, multi-functional chemical intermediate characterized by its piperazine core and trifluoromethyl and formyl functional groups. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering chemists versatile handles for further derivatization. It is primarily needed by pharmaceutical and agrochemical R&D departments for developing new active ingredients, particularly where the introduction of fluorine atoms is desired to modulate lipophilicity, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research pipelines.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds due to its reactive aldehyde group for conjugation.
• Material Science Research: Investigated as a monomer or additive for specialty polymers where fluorine content can impart unique surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	tert-Butyl 4-(2-Formyl-4-(Trifluoromethyl)Phenyl)Piperazine-1-Carboxylate
CAS No.	626219-95-2
Molecular Formula	C17H21F3N2O3
Molecular Weight	358.36 g/mol
Synonyms	1-Boc-4-(2-Formyl-4-(trifluoromethyl)phenyl)piperazine; tert-Butyl 4-[2-formyl-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate; 4-(2-Formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester; 626219-95-2; 1-Piperazinecarboxylic acid, 4-[2-formyl-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester; Boc-4-(2-formyl-4-trifluoromethylphenyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Formyl-4-(Trifluoromethyl)Phenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.