Description

((1S,3R)-1-Isopropyl-3-((3S,4R)-3-Methoxytetrahydro-2H-Pyran-4-Ylamino)Cyclopentyl)(3-(Trifluoromethyl)-7,8-Dihydro-1,6-Naphthyridin-6(5H)-Yl)Methanone Succinate CAS NO 624733-89-7 is a high-purity, non-racemic chiral compound designed for advanced pharmaceutical research and development. This complex organic molecule, featuring a naphthyridine core and a succinate salt form, is engineered to provide a critical building block for novel therapeutic agents, particularly in targeted drug discovery. It is essential for medicinal chemists and process development scientists working in oncology, neurology, and other specialized therapeutic areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potent, selective active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug candidates.
• Process Chemistry & Scale-Up: Provides a defined, high-quality starting material for optimizing synthetic routes from lab to pilot plant scale.
• Reference Standard: Acts as an analytical standard for method development, quality control, and regulatory submissions.
• Biochemical Probe Development: Utilized in creating tools for studying specific biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	((1S,3R)-1-Isopropyl-3-((3S,4R)-3-Methoxytetrahydro-2H-Pyran-4-Ylamino)Cyclopentyl)(3-(Trifluoromethyl)-7,8-Dihydro-1,6-Naphthyridin-6(5H)-Yl)Methanone Succinate
CAS No.	624733-89-7
Molecular Formula	C29H38F3N3O5
Molecular Weight	565.63 g/mol
Synonyms	Succinic acid; (1S,3R)-1-Isopropyl-3-[(3S,4R)-3-methoxyoxan-4-yl]aminocyclopentyl]-(3-trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl)methanone; (1S,3R)-1-Isopropyl-3-((3S,4R)-3-methoxytetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxylic acid (3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl)methanone succinate; Naphthyridine succinate derivative; Chiral naphthyridine intermediate; Pharmaceutical intermediate 624733-89-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.