Description

4-(5-Bromo-Thiazol-2-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a brominated thiazole core linked to a piperazine scaffold with a Boc-protecting group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the thiazole-piperazine pharmacophore.
• Protease Inhibitor Development: Serves as a precursor for compounds designed to inhibit specific enzymes, such as kinases or proteases.
• CNS Drug Discovery: Applied in the research of central nervous system (CNS) active compounds due to the favorable properties of the piperazine moiety.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of complex molecules under cGMP conditions.

Basic Information

Product Name	4-(5-Bromo-Thiazol-2-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	623588-36-3
Molecular Formula	C12H18BrN3O2S
Molecular Weight	348.26 g/mol
Synonyms	tert-Butyl 4-(5-bromothiazol-2-yl)piperazine-1-carboxylate; 1-Boc-4-(5-bromothiazol-2-yl)piperazine; 4-(5-Bromo-1,3-thiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(5-bromothiazol-2-yl)piperazine; 2-(1-Boc-piperazin-4-yl)-5-bromothiazole; 5-Bromo-2-(1-Boc-piperazin-4-yl)thiazole; N-Boc-4-(5-bromothiazol-2-yl)piperazine
EINECS	Contact for details

Quality Control

Our production of 4-(5-Bromo-Thiazol-2-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.