Description

1-Cbz-(R)-3-Methylpiperazine is a chiral, N-protected piperazine derivative of significant importance in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Peptidomimetics & Bioactive Molecules: Used to incorporate the (R)-3-methylpiperazine moiety into peptide backbones and other bioactive scaffolds to modulate biological activity and pharmacokinetic properties.
• Agrochemical Research: Serves as a building block for developing new chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and receptor interactions.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis services catering to the needs of biotechnology and pharmaceutical companies.

Basic Information

Product Name	1-Cbz-(R)-3-Methylpiperazine
CAS No.	623586-00-5
Molecular Formula	C14H20N2O2
Molecular Weight	248.32 g/mol
Synonyms	Carbobenzyloxy-(R)-3-methylpiperazine; (R)-1-(Benzyloxycarbonyl)-3-methylpiperazine; (R)-1-Cbz-3-methylpiperazine; (R)-3-Methyl-1-[(phenylmethoxy)carbonyl]piperazine; (R)-N-Cbz-3-methylpiperazine; 1-[(Benzyloxy)carbonyl]-(3R)-methylpiperazine; Benzyl (R)-3-methylpiperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-Cbz-(R)-3-Methylpiperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.