Description

1-Cbz-3R,5S-Dimethylpiperazine is a high-purity, stereochemically defined chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules where precise stereochemistry is essential for biological activity and regulatory approval. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drugs.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex, stereochemically pure molecules in medicinal chemistry and process development.
• Agrochemical Research: Used in the synthesis of advanced, enantiomerically pure crop protection agents and pesticides.
• Ligand and Catalyst Preparation: Acts as a precursor for chiral ligands and organocatalysts used in stereoselective transformations.
• Peptidomimetics Development: Incorporated into the backbone of peptide analogs to enhance metabolic stability and bioavailability.
• Academic & Contract Research: Employed in academic laboratories and CROs (Contract Research Organizations) for exploratory chemistry and method development.

Basic Information

Product Name	1-Cbz-3R,5S-Dimethylpiperazine
CAS No.	623585-97-7
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	(3R,5S)-1-[(Benzyloxy)carbonyl]-3,5-dimethylpiperazine; 1-Carbobenzoxy-(3R,5S)-dimethylpiperazine; 1-Cbz-(3R,5S)-dimethylpiperazine; (3R,5S)-1-Cbz-3,5-Dimethylpiperazine; N-Cbz-(3R,5S)-Dimethylpiperazine; Benzyl (3R,5S)-3,5-dimethylpiperazine-1-carboxylate; Z-(3R,5S)-Dimethylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Cbz-3R,5S-Dimethylpiperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical development. A detailed Certificate of Analysis (COA) documenting identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.