Description

(5R,6Z)-6-[(5,6-Dihydro-8H-Imidazo[2,1-C][1,4]Oxazin-2-Yl)Methylene]-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid Sodium Salt Hydrate is a high-purity, advanced pharmaceutical intermediate belonging to the carbapenem class of β-lactam antibiotics. This compound is critical for the research and development of novel antibacterial agents, offering a sophisticated chemical scaffold for further synthesis. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on antimicrobial discovery and development.

Application

• Key Intermediate for Antibiotic Synthesis: Serves as a crucial building block in the multi-step synthesis of next-generation carbapenem antibiotics.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry programs to develop new antibacterial compounds with improved efficacy and spectrum of activity.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the production of complex β-lactam antibiotic active ingredients under controlled GMP environments.
• Biochemical Research: Utilized in studies investigating bacterial resistance mechanisms and the structure-activity relationships (SAR) of β-lactam drugs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Product Name	(5R,6Z)-6-[(5,6-Dihydro-8H-Imidazo[2,1-C][1,4]Oxazin-2-Yl)Methylene]-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid Sodium Salt Hydrate
CAS No.	623564-40-9
Molecular Formula	C16H14N3NaO5S • xH2O
Molecular Weight	383.36 g/mol (Anhydrous)
Synonyms	Sodium (5R,6Z)-6-[(5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)methylene]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate hydrate; Carbapenem intermediate 623564-40-9; Sodium salt of imidazo-oxazin carbapenem; (5R,6Z)-6-[(Imidazo[2,1-c][1,4]oxazin-2-yl)methylene]penem-3-carboxylate sodium salt; Antibiotic intermediate CAS 623564-40-9; Sodium 6-[(5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)methylene]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
EINECS	Contact for details

Quality Control

Our (5R,6Z)-6-[(5,6-Dihydro-8H-Imidazo[2,1-C][1,4]Oxazin-2-Yl)Methylene]-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid Sodium Salt Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.