Description

Ethyl 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine-2-Carboxylate Dihydrochloride 0.5 Hydrate is a high-purity, non-GMP organic intermediate of significant importance in pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of complex heterocyclic molecules, particularly those targeting neurological and metabolic pathways. It is primarily sought by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology sectors for the production of active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development stages for creating new APIs with imidazopyrazine core structures.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API production.

Basic Information

Product Name	Ethyl 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine-2-Carboxylate Dihydrochloride 0.5 Hydrate
CAS No.	623564-18-1
Molecular Formula	C9H16Cl2N4O2.5
Molecular Weight	307.16 g/mol (Anhydrous free base: 210.25 g/mol)
Synonyms	Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate dihydrochloride hemihydrate; Imidazo[1,2-a]pyrazine-2-carboxylic acid, 5,6,7,8-tetrahydro-, ethyl ester, dihydrochloride, hydrate (1:0.5); 623564-18-1; UNII-9K5B8BZ9VJ; 9K5B8BZ9VJ; Ethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate HCl; SCHEMBL23306227.
EINECS	Contact for details

Quality Control

Our Ethyl 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine-2-Carboxylate Dihydrochloride 0.5 Hydrate is produced and controlled under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for water content, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability, batch-to-batch consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed after opening to minimize exposure to atmospheric moisture and light, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	2.0% - 4.0% (Theoretical for 0.5 hydrate: ~2.9%)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.