Description

2-Bromo-5-Iodopyrazine is a high-purity halogenated heterocyclic building block essential for advanced organic synthesis. This compound is valued for its dual reactive sites, enabling selective cross-coupling reactions and functional group transformations critical for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides by providing a versatile pyrazine core for structural modification.
• Material Science: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Cross-Coupling Reactions: Employed in Suzuki, Stille, and Negishi couplings to introduce bromo and iodo functional groups into complex molecules.
• Chemical Biology: Useful as a probe or linker in bioconjugation chemistry and for labeling biomolecules.
• Academic & Contract Research: A valuable reagent for methodological development and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	2-Bromo-5-Iodopyrazine
CAS No.	622392-04-5
Molecular Formula	C4H2BrIN2
Molecular Weight	284.88 g/mol
Synonyms	5-Iodo-2-bromopyrazine; 2-Bromo-5-iodopyrazine; Pyrazine, 2-bromo-5-iodo-; Bromoiodopyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Iodopyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support cGMP and ISO 9001 compliant workflows for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and atmospheric oxygen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.