Description

tert-Butyl 4-(Aminomethyl)-4-(3-Fluorophenyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with both amino and fluorophenyl functional groups. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of targeted drug candidates with enhanced pharmacokinetic properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: Serves as a precursor for potential therapeutics targeting neurological disorders, leveraging the fluorophenyl and piperidine motifs.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitors for oncology and inflammatory disease research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Academic & Industrial R&D: Used in academic laboratories and industrial R&D departments for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	tert-Butyl 4-(Aminomethyl)-4-(3-Fluorophenyl)Piperidine-1-Carboxylate
CAS No.	619292-31-8
Molecular Formula	C17H25FN2O2
Molecular Weight	308.39 g/mol
Synonyms	1-Boc-4-(aminomethyl)-4-(3-fluorophenyl)piperidine; 4-(Aminomethyl)-4-(3-fluorophenyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(aminomethyl)-4-(3-fluorophenyl)-1-piperidinecarboxylate; 4-(3-Fluorophenyl)-4-(aminomethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-(aminomethyl)-4-(3-fluorophenyl)piperidine; Boc-4-(aminomethyl)-4-(3-fluorophenyl)piperidine; 619292-31-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Aminomethyl)-4-(3-Fluorophenyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications in research and pre-clinical development, with the capability to scale under cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.