Description

Piperidine, 1-(Chloroacetyl)-4,4-Difluoro- (9Ci) is a high-value, multi-functional piperidine derivative characterized by its chloroacetyl and difluoro substituents. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex molecules. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its difluorinated piperidine scaffold.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and other functional materials where fluorinated heterocycles impart desired properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up campaigns in fine chemical production.

Basic Information

Product Name	Piperidine, 1-(Chloroacetyl)-4,4-Difluoro- (9Ci)
CAS No.	619254-09-0
Molecular Formula	C7H10ClF2NO
Molecular Weight	197.61 g/mol
Synonyms	1-(Chloroacetyl)-4,4-difluoropiperidine; 4,4-Difluoro-1-(chloroacetyl)piperidine; 1-Chloroacetyl-4,4-difluoropiperidine; N-(Chloroacetyl)-4,4-difluoropiperidine; 4,4-Difluoropiperidine-1-carboxylic acid chloride (incorrect but common misnomer); 619254-09-0; (4,4-Difluoropiperidin-1-yl)-2-chloroethanone
EINECS	Contact for details

Quality Control

Every batch of Piperidine, 1-(Chloroacetyl)-4,4-Difluoro- (9Ci) is produced and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.