Description

Piperazine, 2-(4-Fluorophenyl)-, (2S)- (9Ci) is a chiral piperazine derivative characterized by a stereogenic center and a fluorinated aromatic ring, making it a valuable synthetic intermediate. This compound is significant for its role in constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) where its specific stereochemistry and fluorine substitution are critical for biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, especially within the fields of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of potential drug candidates, particularly for neurological and psychiatric disorders.
• API Development: Used in research and process chemistry for constructing the core scaffold of advanced pharmaceutical compounds.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in stereoselective chemical reactions to produce enantiomerically pure products.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead molecules.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.
• Preclinical & Clinical Trial Material: Supplied for the synthesis of compounds required for toxicology studies and clinical trial batches.

Basic Information

Product Name	Piperazine, 2-(4-Fluorophenyl)-, (2S)- (9Ci)
CAS No.	612507-29-6
Molecular Formula	C10H13FN2
Molecular Weight	180.22 g/mol
Synonyms	(2S)-2-(4-Fluorophenyl)piperazine; (S)-2-(4-Fluorophenyl)piperazine; 2-(4-Fluorophenyl)piperazine, (S)-; (S)-4-Fluorophenylpiperazine; L-2-(4-Fluorophenyl)piperazine; (-)-2-(4-Fluorophenyl)piperazine; (S)-1-(4-Fluorophenyl)piperazine (common misassignment); 612507-29-6
EINECS	Contact for details

Quality Control

Our Piperazine, 2-(4-Fluorophenyl)-, (2S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.