Description

2,5-Piperazinedione, 3-[(4-Methylphenyl)Methyl]-, (3S)- (9Ci) is a chiral, substituted diketopiperazine derivative, a privileged scaffold in medicinal chemistry. This compound serves as a critical chiral building block or intermediate in the synthesis of more complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly for creating constrained peptide mimetics and investigating structure-activity relationships.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors or receptor modulators.
• Peptidomimetic Research: Serves as a constrained scaffold for designing and synthesizing peptidomimetics to improve metabolic stability and bioavailability of peptide-based drug candidates.
• Chemical Biology Probes: Used in the construction of specialized probes for studying enzyme mechanisms or protein-protein interactions.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in asymmetric synthesis routes to introduce specific stereochemistry.
• Academic & Industrial R&D: Fundamental building block in organic and medicinal chemistry research within university laboratories and corporate R&D departments.

Basic Information

Product Name	2,5-Piperazinedione, 3-[(4-Methylphenyl)Methyl]-, (3S)- (9Ci)
CAS No.	612502-10-0
Molecular Formula	C13H16N2O2
Molecular Weight	232.28 g/mol
Synonyms	(3S)-3-[(4-Methylphenyl)methyl]piperazine-2,5-dione; (3S)-3-(4-Methylbenzyl)-2,5-piperazinedione; (S)-3-(p-Tolylmethyl)-2,5-diketopiperazine; (S)-3-(4-Methylbenzyl)piperazine-2,5-dione; 3-[(4-Methylphenyl)methyl]-2,5-piperazinedione, (3S)-; (S)-3-(4-Methylbenzyl)-2,5-dioxopiperazine; Chiral Diketopiperazine Derivative; p-Methylbenzyl-substituted (S)-DKP
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione, 3-[(4-Methylphenyl)Methyl]-, (3S)- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.