Description

(S)-1-[(R)-2-Methoxy-1-(4-Trifluoromethyl-Phenyl)-Ethyl]-2-Methyl-Piperazine is a high-purity, chiral piperazine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block or intermediate for the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries seeking to introduce specific stereochemistry into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel therapeutic agents.
• API Development: Used in the development and scale-up of Active Pharmaceutical Ingredients, especially for neurological and psychiatric applications.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce high enantioselectivity.
• Medicinal Chemistry Research: A valuable scaffold for constructing compound libraries in drug discovery programs targeting specific receptors.
• Process Chemistry: Utilized in the optimization and manufacturing routes for complex, stereochemically defined molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	(S)-1-[(R)-2-Methoxy-1-(4-Trifluoromethyl-Phenyl)-Ethyl]-2-Methyl-Piperazine
CAS No.	612494-07-2
Molecular Formula	C15H21F3N2O
Molecular Weight	302.34 g/mol
Synonyms	(S)-1-[(R)-2-Methoxy-1-(4-Trifluoromethylphenyl)ethyl]-2-methylpiperazine; (S,R)-1-(2-Methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-2-methylpiperazine; 2-Methyl-1-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-(S)-piperazine; UNII-9J8K3A9U4Q; 9J8K3A9U4Q; CAS 612494-07-2
EINECS	Contact for details

Quality Control

Our (S)-1-[(R)-2-Methoxy-1-(4-Trifluoromethyl-Phenyl)-Ethyl]-2-Methyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) documenting purity, chiral assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.