Description

Methyl 5-Oxo-6-(2-Trifluoromethylphenylamino)-1,2,3,5-Tetrahydroindolizine-8-Carboxylate is a high-value, advanced pharmaceutical intermediate characterized by its unique indolizine core and trifluoromethylphenylamino substituent. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic research institutions focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• API Development: Serves as a precursor in the development of Active Pharmaceutical Ingredients (APIs) with enhanced metabolic stability and bioavailability, often attributed to the trifluoromethyl group.
• Biochemical Tool Compound: Utilized in biochemical assays and as a probe to study specific biological interactions and enzyme inhibition.
• Custom Synthesis: Starting material for the custom synthesis of complex, fluorinated heterocyclic compounds for specialized client projects.

Basic Information

Product Name	Methyl 5-Oxo-6-(2-Trifluoromethylphenylamino)-1,2,3,5-Tetrahydroindolizine-8-Carboxylate
CAS No.	612065-22-2
Molecular Formula	C19H17F3N2O3
Molecular Weight	378.35 g/mol
Synonyms	Methyl 5-oxo-6-[(2-(trifluoromethyl)phenyl]amino]-1,2,3,5-tetrahydro-8H-indolizine-8-carboxylate; 8H-Indolizine-8-carboxylic acid, 1,2,3,5-tetrahydro-5-oxo-6-[[2-(trifluoromethyl)phenyl]amino]-, methyl ester; 6-(2-Trifluoromethylphenylamino)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylic acid methyl ester; CAS 612065-22-2
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Oxo-6-(2-Trifluoromethylphenylamino)-1,2,3,5-Tetrahydroindolizine-8-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.