Description

8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine is a high-value, nitrogen-rich heterocyclic compound featuring a fused triazolopyrazine core with a trifluoromethyl substituent. This unique structure makes it a critical advanced pharmaceutical intermediate for the synthesis of novel active ingredients, particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Material Science: Serves as a precursor for specialty chemicals and functional materials requiring fluorine-containing heterocycles.
• Academic & Contract Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
CAS No.	611240-66-5
Molecular Formula	C8H9F3N4
Molecular Weight	218.18 g/mol
Synonyms	8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; 5,6,7,8-Tetrahydro-8-methyl-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine; 611240-66-5; Triazolopyrazine derivative; Fused triazole-pyrazine intermediate; Trifluoromethyl triazolopyrazine
EINECS	Contact for details

Quality Control

Our production of 8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.