Description

Gsk 742457 CAS NO 607742-55-2 is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate, representing a critical building block in modern antiviral pharmaceutical synthesis. Its precise chemical structure is essential for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). This compound is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antiviral therapies, particularly for HIV treatment.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the manufacture of non-nucleoside reverse transcriptase inhibitor (NNRTI) APIs.
• Antiviral Drug Research: Used in medicinal chemistry and process development for novel HIV treatment candidates.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for antiviral compounds.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Item	Details
Product Name	Gsk 742457
CAS No.	607742-55-2
Molecular Formula	C20H21FN6O2
Molecular Weight	396.42 g/mol
Synonyms	GSK742457; GSK-742457; 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile; Doravirine Intermediate; MK-1439 Intermediate; Pifeltri Intermediate; (2E)-3-[4-({4-[(4-Cyanophenyl)amino]-2-pyrimidinyl}amino)-3,5-dimethylphenyl]-2-propenenitrile
EINECS	Contact for details

Quality Control

Our Gsk 742457 is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are supplied with each shipment, detailing all critical quality attributes. The production adheres to cGMP guidelines suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.