Description

Piperazine, 1-(2-Methoxyphenyl)-4-[(1,2,4-Triazolo[4,3-A]Pyrimidin-3-Ylthio)Acetyl]- (9Ci) is a sophisticated heterocyclic organic compound that serves as a key advanced intermediate in modern synthetic chemistry. This molecule is valued for its unique structural features, combining a piperazine core with methoxyphenyl and triazolopyrimidinylthioacetyl moieties, which are critical for imparting specific biological and physicochemical properties. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the discovery and synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds.

Application

This specialized piperazine derivative finds its primary utility in advanced research and development settings. Its applications are driven by its role as a versatile building block.

• Pharmaceutical Intermediate: Serves as a critical precursor in the multistep synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• Biochemical Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme inhibition, receptor binding, and other biological mechanisms at a cellular level.
• Agrochemical Research: Investigated as an intermediate for developing new generation pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Academic & Institutional R&D: Utilized in university and government laboratories for fundamental research in organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Product Name	Piperazine, 1-(2-Methoxyphenyl)-4-[(1,2,4-Triazolo[4,3-A]Pyrimidin-3-Ylthio)Acetyl]- (9Ci)
CAS No.	606121-75-9
Molecular Formula	C18H18N6O2S
Molecular Weight	382.44 g/mol
Synonyms	1-(2-Methoxyphenyl)-4-[(1,2,4-triazolo[4,3-a]pyrimidin-3-ylthio)acetyl]piperazine; 1-(2-Methoxyphenyl)-4-({[1,2,4]triazolo[4,3-a]pyrimidin-3-yl}sulfanyl)acetylpiperazine; 1-(2-Methoxyphenyl)-4-[(1,2,4-triazolo[4,3-a]pyrimidin-3-ylthio)acetyl]piperazine (9CI); CAS 606121-75-9; 1-(2-Methoxyphenyl)-4-({[1,2,4]triazolo[4,3-a]pyrimidin-3-yl}thio)acetylpiperazine; 4-[(1,2,4-Triazolo[4,3-a]pyrimidin-3-ylsulfanyl)acetyl]-1-(2-methoxyphenyl)piperazine.
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Production follows cGMP guidelines where applicable, and each batch is subjected to comprehensive analytical testing including HPLC, NMR, and mass spectrometry to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, and residual solvents to ensure the material meets your specific research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.