Description

Piperazine, 1-(3-Chlorophenyl)-4-[[1-(2-Pyrimidinyl)-4-Piperidinyl]Carbonyl]- (9Ci) is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound matters for its role as a critical building block in the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. Pharmaceutical R&D teams and fine chemical manufacturers need this precisely controlled intermediate to ensure the integrity and efficacy of their final drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural moiety in the multi-step synthesis of complex APIs.
• Biochemical Research: Used in life science research for studying receptor-ligand interactions and developing assay standards.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for cGMP-compliant production of clinical trial materials.
• Medicinal Chemistry: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.

Basic Information

Product Name	Piperazine, 1-(3-Chlorophenyl)-4-[[1-(2-Pyrimidinyl)-4-Piperidinyl]Carbonyl]- (9Ci)
CAS No.	605621-28-1
Molecular Formula	C22H24ClN5O
Molecular Weight	409.91 g/mol
Synonyms	1-(3-Chlorophenyl)-4-[[1-(2-pyrimidinyl)-4-piperidinyl]carbonyl]piperazine; 4-[(1-(Pyrimidin-2-yl)piperidin-4-yl)carbonyl]-1-(3-chlorophenyl)piperazine; UNII-9Q1W8K2G0T; 9Q1W8K2G0T; 1-(3-Chlorophenyl)-4-(1-(pyrimidin-2-yl)piperidine-4-carbonyl)piperazine; 605621-28-1 (CAS); Piperazine derivative with chlorophenyl and pyrimidinylpiperidinylcarbonyl groups
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(3-Chlorophenyl)-4-[[1-(2-Pyrimidinyl)-4-Piperidinyl]Carbonyl]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.