Description

Piperazine, 1-[(4-Fluorophenyl)Sulfonyl]-4-(1-Methyl-1H-Benzimidazol-2-Yl)- (9Ci) is a high-value, synthetically derived organic compound featuring a piperazine core functionalized with a fluorophenylsulfonyl group and a methylbenzimidazole moiety. This specific molecular architecture makes it a critical advanced pharmaceutical intermediate (API) for research and development in medicinal chemistry. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly those targeting central nervous system and oncological pathways.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, especially those with benzimidazole and piperazine pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Potential intermediate in the research of enzyme inhibitors due to its sulfonyl and heterocyclic structure.
• Kinase Inhibitor Synthesis: Applied in the development of targeted cancer therapies, where the benzimidazole component is a common scaffold.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Piperazine, 1-[(4-Fluorophenyl)Sulfonyl]-4-(1-Methyl-1H-Benzimidazol-2-Yl)- (9Ci)
CAS No.	604741-58-4
Molecular Formula	C18H19FN4O2S
Molecular Weight	374.44 g/mol
Synonyms	1-[(4-Fluorophenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)piperazine; 4-(1-Methyl-1H-benzimidazol-2-yl)-1-[(4-fluorophenyl)sulfonyl]piperazine; 1-(4-Fluorobenzenesulfonyl)-4-(1-methyl-1H-benzimidazol-2-yl)piperazine; N-[(4-Fluorophenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)piperazine; 604741-58-4; 1-(4-Fluorophenylsulfonyl)-4-(1-methylbenzimidazol-2-yl)piperazine
EINECS	Contact for details

Quality Control

Our production of this high-purity pharmaceutical intermediate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and impurity profiling, NMR and MS for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or cGMP-grade requirements. Our quality system is designed to support regulatory filings and advanced R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed when not in use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.