Description

2-Amino-5-(Trifluoromethyl)Pyrazine is a high-value heterocyclic building block characterized by its pyrazine core substituted with an amino group and a trifluoromethyl group. This unique structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the introduction of fluorine atoms is known to enhance metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazine moiety.
• Material Science Precursor: Serves as a building block for specialty chemicals, including ligands for catalysis and monomers for advanced polymers.
• Research & Development: Essential for medicinal chemistry programs and structure-activity relationship (SAR) studies in academic and industrial laboratories.
• Fluorine Chemistry: A valuable reagent for introducing the trifluoromethyl group into complex molecular architectures, a common strategy in modern drug design.

Basic Information

Product Name	2-Amino-5-(Trifluoromethyl)Pyrazine
CAS No.	69816-38-2
Molecular Formula	C5H4F3N3
Molecular Weight	163.10 g/mol
Synonyms	5-(Trifluoromethyl)pyrazin-2-amine; 2-Amino-5-trifluoromethylpyrazine; 5-(Trifluoromethyl)-2-pyrazinamine; 2-Pyrazinamine, 5-(trifluoromethyl)-; 69816-38-2; 2-Amino-5-(trifluoromethyl)pyrazine; 5-Trifluoromethyl-2-aminopyrazine
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(Trifluoromethyl)Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.