Description

2-Thiazolidineacetic Acid, 4-Carboxy-α-[[[3-(2-Chloro-6-Fluorophenyl)-5-Methyl-4-Isoxazolyl]Carbonyl]Amino]-5,5-Dimethyl-, Disodium Salt, [2R-[2α(R*),4β]]- (9Ci) is a high-purity, complex organic salt with a defined stereochemistry, serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its precise molecular architecture makes it an essential building block for the research and development of novel therapeutic agents, particularly in targeted drug discovery programs. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting specific enzymatic pathways.
• Protease Inhibitor Research: Used in the development and study of novel protease inhibitors due to its specific structural motifs.
• Chemical Biology Probes: Serves as a scaffold or precursor for creating specialized molecular probes to study biological mechanisms at the cellular level.
• Process Chemistry Development: Employed in optimizing scalable synthetic routes for potential new chemical entities (NCEs) during pre-clinical and clinical development phases.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct molecules with high enantiomeric purity.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the global pharmaceutical market.

Basic Information

Product Name	2-Thiazolidineacetic Acid, 4-Carboxy-α-[[[3-(2-Chloro-6-Fluorophenyl)-5-Methyl-4-Isoxazolyl]Carbonyl]Amino]-5,5-Dimethyl-, Disodium Salt, [2R-[2α(R*),4β]]- (9Ci)
CAS No.	69242-35-9
Molecular Formula	C19H18ClFN3Na2O7S
Molecular Weight	528.86 g/mol
Synonyms	Disodium (2R,4R)-4-Carboxy-α-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-5,5-dimethyl-2-thiazolidineacetate; (2R,4R)-4-Carboxy-α-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-5,5-dimethyl-2-thiazolidineacetic Acid Disodium Salt; 69242-35-9; [2R-[2α(R*),4β]]-2-Thiazolidineacetic acid, 4-carboxy-α-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-5,5-dimethyl-, disodium salt; A complex thiazolidine-isoxazole derivative disodium salt.
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet the requirements of cGMP, ICH Q7, and other relevant pharmaceutical guidelines for investigational materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere if specified and opened in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.