Description

(5R)-3-[[(E)-2-(Acetylamino)Ethenyl]Thio]-6β-Isopropyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid CAS NO 69242-34-8 is a high-purity, advanced pharmaceutical intermediate belonging to the β-lactam class of compounds. This specialized chemical is critical for the research and development of novel antibiotics and other therapeutic agents targeting resistant bacterial strains. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and synthetic organic chemistry.

Application

• Key Intermediate in Antibiotic Synthesis: Serves as a crucial building block in the multi-step synthesis of next-generation β-lactam antibiotics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new antimicrobial agents with improved efficacy and spectrum of activity.
• Process Development & Scale-Up: Employed in the optimization and pilot-scale production of active pharmaceutical ingredients (APIs) for clinical trials.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies related to bacterial cell wall synthesis and resistance mechanisms.
• Fine Chemical Manufacturing: Supplied to contract manufacturing organizations (CMOs) for the production of custom, high-value pharmaceutical compounds.

Basic Information

Product Name	(5R)-3-[[(E)-2-(Acetylamino)Ethenyl]Thio]-6β-Isopropyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid
CAS No.	69242-34-8
Molecular Formula	C15H20N2O4S
Molecular Weight	324.40 g/mol
Synonyms	(5R)-3-[(E)-2-(Acetylamino)ethenyl]thio]-6-(1-methylethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; 6β-Isopropylpenem-3-carboxylic acid derivative; Penem intermediate; 3-[(1-Acetamidovinyl)thio]-6β-isopropyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-6-[(R)-1-Hydroxyethyl]-3-[[(E)-2-(acetylamino)ethenyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (related isomer); β-lactam intermediate 69242-34-8.
EINECS	Contact for details

Quality Control

Our (5R)-3-[[(E)-2-(Acetylamino)Ethenyl]Thio]-6β-Isopropyl-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.