Description

Insulin, Arg(B31,B32)- CAS NO 68859-20-1 is a specifically engineered insulin analogue where arginine residues are substituted at positions B31 and B32 of the B-chain. This modification is critical for enhancing the molecule's stability and altering its pharmacokinetic profile, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by biopharmaceutical companies and research institutions focused on developing next-generation diabetes therapies and studying peptide hormone structure-activity relationships.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis and development of novel, long-acting insulin analogues for diabetes treatment.
• Biomedical Research: Used in preclinical studies to investigate the effects of specific amino acid substitutions on insulin receptor binding affinity, metabolic activity, and stability.
• Reference Standard: Acts as a characterized reference material in analytical laboratories for method development and quality control of insulin-based products.
• Process Development: Employed in the scale-up and optimization of recombinant DNA or peptide synthesis manufacturing processes for therapeutic proteins.

Basic Information

Product Name	Insulin, Arg(B31,B32)-
CAS No.	68859-20-1
Molecular Formula	C257H383N65O77S6
Molecular Weight	~5807.5 g/mol
Synonyms	B31,B32-Diarginine Insulin; [ArgB31,ArgB32]-Insulin; Insulin (Arg31, Arg32); Insulin analogue (B31-Arg, B32-Arg); Insulin, Arg(B31)-, Arg(B32)-; Diarginyl-insulin; Long-acting insulin analogue intermediate; Insulin B-chain (22-30)-Arg-Arg-
EINECS	Contact for details

Quality Control

Our Insulin, Arg(B31,B32)- is produced and controlled under strict quality management systems. Each batch is subjected to a comprehensive battery of analytical tests, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting purity, peptide content, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept under desiccated conditions upon opening to maintain stability and prevent degradation. For long-term storage, keep containers sealed in a freezer.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 10.0%
Acetic Acid Content (HPLC)	≤ 15.0%
Biological Activity	To be specified per grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.