Description

Helenalin Methacrylate is a specialized methacrylate derivative of the sesquiterpene lactone helenalin, a compound of significant interest in biochemical research. This product is crucial for researchers and developers seeking to create novel bioactive conjugates or probes, leveraging the potent biological activity of the helenalin core. It is primarily utilized in advanced pharmaceutical research, medicinal chemistry, and the development of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in oncology research.
• Bioconjugation & Probe Development: Used to attach the helenalin pharmacophore to antibodies, proteins, or other targeting molecules for creating antibody-drug conjugates (ADCs) or activity-based probes.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a handle for further chemical modification of the helenalin scaffold.
• Biochemical Tool Compound: Employed in studies investigating NF-κB pathway inhibition and other mechanisms associated with sesquiterpene lactones.
• Polymer-Bound Active Ingredients: The methacrylate group allows for incorporation into polymeric drug delivery systems or functional biomaterials.

Basic Information

Product Name	Helenalin Methacrylate
CAS No.	68798-43-6
Molecular Formula	C19H24O5
Molecular Weight	332.39 g/mol
Synonyms	Helenalin 2-methylacrylate; 2-Propenoic acid, 2-methyl-, (1aR,4E,6aS,7R,9aS,9bR)-1a,2,3,6a,7,8,9a,9b-octahydro-1a,5-dimethyl-7-(1-methylethenyl)-4-oxo-4H-oxireno[2',3':3,3a]azuleno[6,5-b]furan-9-yl ester; Helenalin methacrylic acid ester; Methacrylic acid helenalin ester
EINECS	Contact for details

Quality Control

Our Helenalin Methacrylate is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Allow the container to reach room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.