Description

[(1R,8S)-2,3,5,6,7,8-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl (2R)-2-Hydroxy-2-(1-Hydroxyethyl)-3-Methyl-Butanoate is a high-purity, stereochemically defined organic compound of significant interest in advanced chemical synthesis. This molecule serves as a critical chiral intermediate or building block for the development of complex, biologically active molecules. It is primarily sought after by pharmaceutical R&D and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for alkaloid-derived therapeutics.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective organic synthesis to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Item	Details
Product Name	[(1R,8S)-2,3,5,6,7,8-Hexahydro-1H-Pyrrolizin-1-Yl]Methyl (2R)-2-Hydroxy-2-(1-Hydroxyethyl)-3-Methyl-Butanoate
CAS No.	68473-86-9
Molecular Formula	C15H25NO4
Molecular Weight	283.36 g/mol
Synonyms	(1R,8S)-2,3,5,6,7,8-Hexahydro-1H-pyrrolizin-1-ylmethyl (2R)-2-hydroxy-2-(1-hydroxyethyl)-3-methylbutanoate; Loline derivative; Pyrrolizine alkaloid ester; (R,R)-Loline ester intermediate; 1-Pyrrolizinemethanol, α-ethenyl-α-(1-hydroxyethyl)-3-methylbutanoate (ester), (1R,8S)-rel-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested to ensure identity, purity, and stereochemical integrity, with specifications typically aligned with pharmaceutical-grade requirements. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, and related substances is provided with each shipment to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.