Description

Insulin, Ala(A1)- is a specifically engineered insulin analogue where the first amino acid of the A-chain has been substituted with alanine. This modification is of significant interest in pharmaceutical research for studying insulin's structure-activity relationships and developing novel therapeutic agents. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector. This product is essential for advanced biochemical research, metabolic studies, and the development of next-generation diabetes treatments.

Application

• Pharmaceutical Research & Development: Used as a key intermediate and reference standard in the development of novel insulin analogues and biosimilar products.
• Biochemical Studies: Employed to investigate insulin receptor binding kinetics, signal transduction pathways, and structure-function relationships.
• Metabolic Disorder Research: A vital tool for in vitro and in vivo studies aimed at understanding diabetes mellitus and developing new therapeutic strategies.
• Quality Control & Analytical Standards: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and other analytical methods in quality assurance laboratories.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in endocrinology, peptide chemistry, and molecular biology.

Basic Information

Product Name	Insulin, Ala(A1)-
CAS No.	68368-97-8
Molecular Formula	C254H377N65O76S6
Molecular Weight	5807.9 g/mol
Synonyms	Alanine(A1)-Insulin; A1-Ala-Insulin; Insulin A-chain(1-21), 1-L-alanine-; [AlaA1]-Insulin; Insulin analogue (A1-Ala); Human Insulin, Ala1-; Insulin (Ala at position 1 of A chain)
EINECS	Contact for details

Quality Control

Our Insulin, Ala(A1)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, peptide mapping, and mass spectrometry for identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support compliance with relevant guidelines for research-grade active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For extended storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.