Description

Bis(Helenalinyl)Malonate is a specialized sesquiterpene lactone derivative, synthesized from the bioactive natural product helenalin. This compound matters for its role as a key synthetic intermediate and a potential precursor for developing novel bioactive molecules with targeted properties. It is primarily needed by research institutions and pharmaceutical development companies focused on anti-inflammatory, anticancer, and other therapeutic agent discovery programs. The product is supplied with a focus on purity and batch-to-batch consistency for advanced chemical synthesis.

Application

• Pharmaceutical Research Intermediates: Serves as a crucial building block in the synthesis of novel drug candidates, particularly those exploring sesquiterpene lactone pharmacophores.
• Medicinal Chemistry Studies: Used to investigate structure-activity relationships (SAR) and to create analogs for biological screening against various targets.
• Reference Standard: Employed as an analytical standard in quality control laboratories for the identification and quantification of related compounds.
• Biochemical Research: Utilized in studies exploring the mechanisms of action of helenalin-derived compounds, including NF-κB pathway inhibition.
• Academic & Institutional Research: Supports chemical and biological research in universities and government labs focused on natural product derivatives.

Basic Information

Product Name	Bis(Helenalinyl)Malonate
CAS No.	68322-91-8
Molecular Formula	C35H38O10
Molecular Weight	618.67 g/mol
Synonyms	Bis(helenalinyl) malonate; Propanedioic acid, 1,3-bis[(1aR,4E,6aR,7R,7aS,7bS)-decahydro-1a,5-dimethyl-7-(1-methylethenyl)-1-oxo-1H-cyclopropa[e]azulen-4-yl] ester; Helenalin malonate dimer; Dimalonyl dihelenalin
EINECS	Contact for details

Quality Control

Our Bis(Helenalinyl)Malonate is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR, MS) for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed in a dry environment to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.