Description

12-Hpete is a specialized eicosanoid derivative, a key intermediate in the lipoxygenase pathway of arachidonic acid metabolism. This compound is crucial for researchers and manufacturers investigating inflammatory and immune response mechanisms at a biochemical level. It is primarily utilized in pharmaceutical R&D, biochemical studies, and as a reference standard for analytical purposes.

Application

• Biochemical Research: Critical intermediate for studying the 12-lipoxygenase (12-LOX) enzymatic pathway and eicosanoid biosynthesis.
• Pharmaceutical Development: Used as a reference compound and precursor in the development of anti-inflammatory and immunomodulatory drug candidates.
• Cell Signaling Studies: Employed in vitro to investigate its role as a signaling molecule in cellular processes related to inflammation and oxidative stress.
• Analytical Reference Standard: Serves as a high-purity standard for HPLC, LC-MS, and other analytical methods in metabolomics and lipidomics research.
• Enzyme Activity Assays: Used as a substrate to measure and characterize the activity of lipoxygenase enzymes.

Basic Information

Product Name	12-Hpete
CAS No.	67675-13-2
Molecular Formula	C20H32O4
Molecular Weight	336.47 g/mol
Synonyms	12(S)-HPETE; 12(S)-Hydroperoxyeicosatetraenoic Acid; 12-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic Acid; 12(S)-HPETE; 12(S)-HpETE; 12-Hydroperoxyeicosatetraenoate; (12S)-HPETE; Arachidonic acid 12-hydroperoxide
EINECS	Contact for details

Quality Control

Our 12-Hpete is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and stability data. We adhere to cGMP guidelines for the manufacture of advanced pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and strictly light-sensitive (protect from all light exposure), it is recommended to store the product at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity (Chiral HPLC)	≥ 90% (12(S)-isomer)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.