Description

Mpeg-Cooh CAS NO 67665-18-3 is a methoxy poly(ethylene glycol) carboxylic acid, a functionalized polymer widely used as a versatile linker and modifier in advanced chemical synthesis. Its key value lies in its terminal carboxylic acid group, which provides a reactive site for conjugation, enabling the creation of custom-tailored molecules with enhanced solubility and biocompatibility. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty chemical industries, particularly for applications in drug delivery systems, bioconjugation, and surface modification.

Application

• Pharmaceutical PEGylation: Conjugation to peptides, proteins, and oligonucleotides to improve pharmacokinetics, reduce immunogenicity, and enhance solubility.
• Polymer-Drug Conjugates: Acting as a biodegradable linker in prodrug and targeted drug delivery system development.
• Bioconjugation & Labeling: Functionalizing antibodies, enzymes, and other biomolecules with dyes, tags, or other functional groups for diagnostics and research.
• Surface Modification: Crafting hydrophilic, non-fouling coatings on nanoparticles, medical devices, and sensors to improve biocompatibility.
• Hydrogel & Biomaterial Synthesis: Serving as a cross-linking agent or hydrophilic component in the creation of advanced polymeric materials for tissue engineering.
• Specialty Surfactants & Additives: Formulating high-performance, non-ionic surfactants for demanding industrial and cosmetic applications.

Basic Information

Product Name	Mpeg-Cooh
CAS No.	67665-18-3
Molecular Formula	CnH2n+2O(n+2) (n varies by PEG chain length)
Molecular Weight	Variable (Typically 350 - 5000 g/mol). Contact for details on specific grades.
Synonyms	mPEG-COOH; Methoxy PEG carboxylic acid; Methoxy poly(ethylene glycol) acetic acid; α-Methoxy-ω-carboxy poly(ethylene glycol); Poly(ethylene glycol) methyl ether carboxylic acid; PEG methyl ether carboxylate; mPEG-acid; Carboxymethylated methoxy polyethylene glycol; O-(Carboxymethyl)-O'-methylpolyethylene glycol; MPEG-CA
EINECS	Contact for details

Quality Control

Our Mpeg-Cooh is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including determination of acid value, molecular weight distribution (GPC/SEC), and functional group purity (NMR, titration) to ensure consistent performance and batch-to-batch reproducibility. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Complies
Assay (COOH content)	> 95%
Molecular Weight (Mn)	As per ordered grade (e.g., 350, 550, 750, 2000, 5000)
Polydispersity Index (PDI)	< 1.10 (by GPC)
Methoxy Substitution	> 95%
Water Content (KF)	< 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.