Description

Mannosylphosphoryldecaprenol CAS NO 67463-74-5 is a specialized lipid-linked sugar intermediate, specifically a polyprenyl phosphate mannose, that plays a critical role in the biosynthesis of complex cell wall components in certain microorganisms. This compound is essential for researchers and developers in the life sciences sector, particularly those focused on mycobacterial biochemistry and novel antibiotic discovery. It serves as a vital substrate for studying and targeting key enzymatic pathways, such as those involved in the assembly of arabinogalactan and lipoarabinomannan in *Mycobacterium tuberculosis*. Consequently, its primary users are in pharmaceutical R&D, academic research institutions, and biotechnology companies engaged in anti-infective drug development and glycobiology.

Application

• Biochemical Research: Critical substrate for in vitro enzymatic assays to study mannosyltransferase activity in mycobacterial cell wall biosynthesis.
• Drug Discovery & Development: Used in high-throughput screening (HTS) platforms to identify and validate novel inhibitors targeting the mycobacterial membrane protein large (MmpL) transporter system and related pathways.
• Glycobiology Studies: Essential for investigating the biosynthetic pathways of complex glycoconjugates like lipoarabinomannan (LAM) and arabinogalactan in pathogenic bacteria.
• Antibiotic Mechanism of Action: Employed to elucidate the mode of action of existing and potential new anti-tuberculosis agents that interfere with cell wall assembly.
• Enzyme Kinetics & Characterization: Serves as a defined acceptor molecule for purifying and characterizing key glycosyltransferases involved in polyprenol-dependent glycosylation reactions.
• Synthetic Biology: Used as a building block or intermediate in the engineered synthesis of complex bacterial glycans for vaccine development.

Basic Information

Product Name	Mannosylphosphoryldecaprenol
CAS No.	67463-74-5
Molecular Formula	C~75~H~124~O~10~P
Molecular Weight	~1225.8 g/mol
Synonyms	Decaprenylphosphorylmannose; DPM; Mannose-1-phosphodecaprenol; α-D-Mannopyranosylphosphodecaprenol; Polyprenyl phosphate mannose; C50-P-Mannose; (all-E)-3,7,11,15,19,23,27,31,35,39-Decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl (α-D-mannopyranosyl) hydrogen phosphate
EINECS	Contact for details

Quality Control

Our Mannosylphosphoryldecaprenol is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, mass spectrometry (MS) for identity confirmation, and NMR structural verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and specific test results. We adhere to ISO 9001 quality management principles, and our processes are designed to support research requiring materials of the highest integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to ensure long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol/chloroform mixtures; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.