Description

(3A,5B,12A)-12-Hydroxy-Cholan-24-Oic Acid-3-(Sulfooxy) is a chemically modified bile acid derivative, specifically a sulfated hydroxy cholanic acid. This compound is of significant interest in pharmaceutical research and development due to its role as a key intermediate or reference standard for studying bile acid metabolism and related therapeutic pathways. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of bioactive molecules, metabolic probes, or high-purity analytical standards.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel therapeutic agents targeting metabolic and liver-related disorders.
• Biochemical Research: Used as a reference standard or probe in studies of bile acid transporters, nuclear receptors (e.g., FXR, TGR5), and metabolic pathways.
• Analytical Standard: Employed in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for the qualitative and quantitative analysis of bile acid derivatives in biological samples.
• Metabolite Synthesis: Key precursor for the preparation of sulfated bile acid metabolites for in vitro and in vivo studies.
• Enzyme Substrate/Inhibitor Studies: Utilized in enzymatic assays to investigate the activity of sulfotransferases and other modifying enzymes.

Basic Information

Product Name	(3A,5B,12A)-12-Hydroxy-Cholan-24-Oic Acid-3-(Sulfooxy)
CAS No.	67030-48-2
Molecular Formula	C24H40O7S
Molecular Weight	472.63 g/mol
Synonyms	12-Hydroxy-3-sulfooxy-cholan-24-oic acid; 3-Sulfate of 12-Hydroxycholic Acid; 12α-Hydroxycholic acid 3-sulfate; Tauro-12-ketolithocholic acid sulfate (related); Cholane-24-oic acid, 12-hydroxy-, 3-(hydrogen sulfate), (3α,5β,12α)-; 12-Hydroxy-3-sulphooxy-cholan-24-oic acid; 3α-Sulfooxy-12α-hydroxy-5β-cholan-24-oic Acid
EINECS	Contact for details

Quality Control

Our (3A,5B,12A)-12-Hydroxy-Cholan-24-Oic Acid-3-(Sulfooxy) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and relevant physicochemical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.