Description

Talniflumate is a synthetic small molecule belonging to the fenamate class of non-steroidal anti-inflammatory drugs (NSAIDs). Its primary value lies in its potent and selective inhibition of the calcium-activated chloride channel (CaCC), making it a critical research tool and a compound of significant pharmacological interest. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on ion channel physiology, inflammatory pathways, and respiratory diseases.

Application

• Pharmacological Research: A key reference standard and active compound for studying the role of calcium-activated chloride channels (CaCCs) in various physiological and pathological processes.
• Drug Discovery & Development: Used as a lead compound or biochemical tool in preclinical research for conditions where CaCC modulation is relevant, such as cystic fibrosis, asthma, and certain secretory diarrheas.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to identify and characterize novel CaCC inhibitors or to validate assay systems.
• Anti-inflammatory Studies: Investigated for its dual mechanism involving COX inhibition and CaCC blockade, providing insights into novel anti-inflammatory therapeutic strategies.
• Academic Research: Utilized in university and institutional labs for basic science research into ion channel function, cellular signaling, and epithelial transport.

Basic Information

Product Name	Talniflumate
CAS No.	66898-62-2
Molecular Formula	C₁₃H₈F₃N₂O₅
Molecular Weight	329.21 g/mol
Synonyms	2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid; 2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid; 2-((3-(Trifluoromethyl)phenyl)amino)nicotinic acid; Bay o 6976; BAY-o-6976; BAY o6976; Talniflumatum; G-1
EINECS	Contact for details

Quality Control

Our Talniflumate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.