Description

1,25-Dihydroxyvitamin D is the biologically active metabolite of vitamin D, also known as calcitriol, which plays a critical role in calcium and phosphate homeostasis. This compound is essential for research and development in the pharmaceutical and nutraceutical industries, where precise biological activity is paramount. It is primarily utilized by manufacturers of active pharmaceutical ingredients (APIs), clinical research organizations, and developers of advanced therapeutic formulations.

Application

• Pharmaceutical API Synthesis: A key intermediate or active ingredient in prescription medications for treating hypocalcemia, osteoporosis, and renal osteodystrophy.
• Biochemical Research: Used as a reference standard and reagent in studies of vitamin D metabolism, bone biology, and cell differentiation.
• Nutraceutical Formulations: Incorporated into high-potency dietary supplements targeting bone and immune health support.
• Cell Culture & In Vitro Studies: Serves as a critical growth factor and differentiation agent in specialized cell culture media.
• Veterinary Medicine: Employed in formulations for treating calcium and bone disorders in animals.
• Diagnostic Kit Development: Used in the production of calibration standards and reagents for immunoassays measuring vitamin D status.

Basic Information

Product Name	1,25-Dihydroxyvitamin D
CAS No.	66772-14-3
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	Calcitriol; 1,25-Dihydroxycholecalciferol; 1,25(OH)₂D₃; 1,25-Dihydroxyvitamin D3; 1α,25-Dihydroxyvitamin D₃; 1α,25-Dihydroxycholecalciferol; Rocaltrol (trade name); 1,25-DHCC
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxyvitamin D is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) detailing purity, potency, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. This product is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.