Description

(S)-Ketorolac is the single enantiomer of the potent nonsteroidal anti-inflammatory drug (NSAID) ketorolac, specifically targeting the pharmacologically active S-form. This high-purity chiral intermediate is critical for developing enantiomerically pure pharmaceutical formulations, which offer improved therapeutic profiles and reduced side effects. It is essential for advanced pharmaceutical research, process development, and the manufacture of next-generation analgesic and anti-inflammatory APIs targeting global markets.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as the key chiral building block for the production of enantiopure (S)-Ketorolac tromethamine, the active component in prescription pain management drugs.
• Pharmaceutical R&D: Used in preclinical and clinical research to study the specific pharmacokinetics, efficacy, and safety profile of the isolated S-enantiomer.
• Chiral Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development, validation, and impurity profiling of ketorolac-based products.
• Process Chemistry & Scale-Up: Integral to developing and optimizing asymmetric synthesis routes and purification processes for commercial-scale API manufacturing.
• Formulation Development: Used in creating novel drug delivery systems, such as ophthalmic solutions or injectables, that utilize the specific properties of the (S)-enantiomer.

Basic Information

Product Name	(S)-Ketorolac
CAS No.	66635-92-5
Molecular Formula	C15H13NO3
Molecular Weight	255.27 g/mol
Synonyms	(S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; (S)-Ketorolac free acid; (-)-Ketorolac; (S)-(+)-Ketorolac; L-Ketorolac; Toradol (S-enantiomer); (S)-Ketorolac acid
EINECS	Contact for details

Quality Control

Our (S)-Ketorolac is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity, chemical purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity testing, ensuring data integrity and traceability for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Specific Rotation	[α]20/D: Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.