Description

Ketorolac is a potent non-steroidal anti-inflammatory drug (NSAID) belonging to the pyrrolo-pyrrole group of carboxylic acids. Its primary value lies in its effective analgesic and anti-inflammatory properties, making it a critical active pharmaceutical ingredient (API) for pain management formulations. This compound is essential for pharmaceutical manufacturers developing injectable solutions, ophthalmic preparations, and oral tablets targeting post-operative and acute pain relief. Ketorolac CAS NO 66635-83-4 is supplied under stringent quality control to meet the exacting standards of the global pharmaceutical industry.

Application

• Pharmaceutical API: Primary use as the active ingredient in analgesic and anti-inflammatory medications.
• Injectable Formulations: Manufacture of parenteral solutions for hospital use in managing moderate to severe acute pain.
• Ophthalmic Solutions: Key component in eye drops for the treatment of ocular inflammation and pain following cataract surgery.
• Oral Solid Dosage Forms: Used in the production of tablets for short-term pain management.
• Research & Development: Serves as a reference standard and building block in pharmacological and medicinal chemistry research.
• Generic Drug Manufacturing: Critical for producing cost-effective generic versions of branded ketorolac tromethamine products.

Basic Information

Product Name	Ketorolac
CAS No.	66635-83-4
Molecular Formula	C15H13NO3
Molecular Weight	255.27 g/mol
Synonyms	(±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; Ketorolac Free Acid; RS-37619; Toradol (as tromethamine salt); Torolac; Acular (ophthalmic); Ketanov; Zaditen (not to be confused with ketotifen); Ketorol
EINECS	Contact for details

Quality Control

Our Ketorolac is manufactured and tested to meet high-purity pharmacopeial standards. Quality assurance protocols are designed to ensure batch-to-batch consistency and compliance with ICH guidelines and relevant regulatory requirements for active pharmaceutical ingredients (APIs). A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for identity, purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.