Description

Midaglizole is a potent and selective α-2 adrenergic receptor antagonist of significant interest in pharmacological research. Its primary value lies in its ability to modulate sympathetic nervous system activity, making it a critical reference compound for studying cardiovascular and metabolic pathways. This high-purity chemical is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on autonomic nervous system disorders, diabetes research, and novel therapeutic agent development.

Application

• Pharmacological Reference Standard: Serves as a key analytical standard in the quality control and method development for related pharmaceutical compounds.
• Biomedical Research: Used in in vitro and in vivo studies to investigate the role of α-2 adrenergic receptors in various physiological systems.
• Drug Discovery & Development: Acts as a lead compound or a biochemical tool for screening and validating new drug candidates targeting adrenergic pathways.
• Metabolic Disorder Studies: Employed in research exploring the links between the autonomic nervous system, insulin secretion, and glucose homeostasis.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental neuropharmacology and cardiovascular research.
• Active Pharmaceutical Ingredient (API) Intermediate: Can be used in the synthesis and development of more complex therapeutic agents.

Basic Information

Product Name	Midaglizole
CAS No.	66529-17-7
Molecular Formula	C14H16N4O2
Molecular Weight	272.31 g/mol
Synonyms	Midaglizole; DG-5128; 2-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-1H-imidazole; 2-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1H-imidazole; DG5128; (2,3-Dihydro-1,4-benzodioxin-2-yl)methylimidazole; α-2 adrenoceptor antagonist DG-5128
EINECS	Contact for details

Quality Control

Our Midaglizole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, residual solvent analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.