Description

2-Chloro-3-(Piperazin-1-Yl)Pyrazine Hydrochloride is a high-purity, pharmaceutically relevant chemical intermediate with a distinct pyrazine-piperazine core structure. This compound is valued for its role as a versatile building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitor candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel drug candidates.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of diverse compound libraries for screening.
• Bioconjugation & Probe Development: The reactive chloro and basic piperazine groups make it suitable for creating chemical probes and targeted conjugates in biochemical research.

Basic Information

Product Name	2-Chloro-3-(Piperazin-1-Yl)Pyrazine Hydrochloride
CAS No.	66522-30-3
Molecular Formula	C8H12ClN5•HCl
Molecular Weight	266.58 g/mol
Synonyms	2-Chloro-3-(1-piperazinyl)pyrazine hydrochloride; 2-Chloro-3-piperazin-1-ylpyrazine hydrochloride; 3-(Piperazin-1-yl)-2-chloropyrazine hydrochloride; 2-Chloro-3-piperazinylpyrazine monohydrochloride; 2-Chloro-3-(piperazin-1-yl)pyrazine HCl; Pyrazine, 2-chloro-3-(1-piperazinyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.